Following the Mw 7.6 earthquake that struck Azad Jammu & Kashmir on October 8, 2005 — killing an estimated 73,000–86,000 people and displacing over 3.3 million — CMAT deployed at least five medical teams by December 3, with four further rotations scheduled through mid-February 2006, delivering facility-based wound care at Abbas Institute in Muzaffarabad, post-operative and rehabilitation surge support at PIMS in Islamabad, and helicopter-supported mobile outreach to remote, unreached villages. Upon the redeployment of Canadian Forces DART, CMAT was asked to assume staffing of the Garhi Dupatta clinic in partnership with the Pakistan Red Crescent, sustaining approximately 300–400 outpatient consultations per day, while also training and certifying eight local health workers in wound care to strengthen continuity of services. In parallel, CMAT coordinated the distribution of 1,000 winterized tents and 5,000 thermal quilts and blankets to an estimated 3,000 families — approximately 18,000 people — supported by approximately CAD 190,000 in CIDA matching funds and additional grants from Mercy-USA totalling roughly CAD 300,000 for winterization and USD 22,000 for an inflatable field facility.

On 8 Oct 2005, a Mw 7.6 earthquake struck Azad Jammu & Kashmir and NWFP/Khyber Pakhtunkhwa, causing mass casualties, large-scale displacement, and severe damage to health infrastructure. In Muzaffarabad, the Combined Military Hospital was reported out of service; Abbas Institute became the principal functioning hospital in the immediate aftermath. Priority needs included trauma after-care and infection control, primary health care in remote valleys, and rapid winterization to prevent excess morbidity and mortality.

Following the October 2005 Kashmir earthquake, CMAT delivered a multi-modal response across affected areas of Pakistan, opening a wound-care clinic in Muzaffarabad to manage complex wound infections and perform minor amputations when indicated, while also training and certifying eight local staff in wound care to strengthen continuity of quality services. Helicopter-supported mobile teams reached remote settlements to provide primary care, wound management, and triage for air evacuation to referral facilities, while CMAT simultaneously augmented capacity at PIMS for post-operative and rehabilitation care. At Garhi Dupatta, CMAT ensured continuity of outpatient services sustaining approximately 300–400 OPD consultations per day following handover, in partnership with the Pakistan Red Crescent Society. In parallel, CMAT coordinated the procurement and distribution of 1,000 winterized tents and 5,000 quilts and blankets, prioritizing the most vulnerable households and reaching an estimated 3,000 families — approximately 18,000 people — ahead of winter. Throughout the response, CMAT integrated with the WHO Health Cluster, PRCS, IOM, the Shelter Cluster, and Canadian Forces DART, supported by targeted grants from CIDA and Mercy-USA.